Dr. Ghayur has 30+ years of experience leading multi-disciplinary and cross-therapeutic area Biologics discovery programs and developing novel biologics platforms in different organizations – BASF Pharma 1990 – 2001; Abbott Laboratories 2002 – 2013 and AbbVie 2014 – 2021. Several Biologics programs resulted in clinical development candidates. Dr. Ghayur led the team that pioneered the discovery and development of the Dual-variable Domain –Ig (DVD-Ig) bi-specific and other multi-specific platforms (1999 – 2013). Three DVD – Ig molecules entered clinical development for autoimmune and oncology indications. As Distinguished Research Fellow, Head of Biology Focus Areas’ teams (2014 – 2021) and as Head of Foundational Immunology Department (2016 – 2018) at AbbVie, Dr. Ghayur led the team that defined the uptake, intracellular trafficking and degradation of anti-TNF antibodies resulting in the concept of anti-TNF ADC as Next-Gen anti-TNFs. In addition, he initiated/supervised several programs (mAbs, bi-specifics & ADCs) that are in various stages of AbbVie’s discovery pipeline. Dr. Ghayur also proposed and helped implement several corporate-wide (Abbott & AbbVie) collaborative initiatives to bring forward innovative therapeutic and technology programs/concepts.
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