Dr. Mayes has worked in the biopharmaceutical industry since 2004. Prior to joining SynDevRx in 2015, he spent 11 years at Idenix Pharmaceuticals working in the field of direct-acting antivirals for the treatment of HBV, HIV and HCV. As director of chemistry, manufacturing and controls, he was responsible for a wide range of activities, including API process R&D, solid-state chemistry, API production, formulation development and CTM manufacturing to enable the rapid progression of Phase 1 and 2 studies. Additionally, he was responsible for leading a focused discovery program into novel nucleosides and nucleotide prodrug inhibitors targeting HCV NS5B polymerase.
Dr. Mayes is the principal inventor of the prodrug technology for IDX21437 (now MK-3682), the key asset within an anti-HCV portfolio for which Idenix was acquired by Merck for $3.85 billion in 2014. He obtained his M.Chem. and D.Phil. (Ph.D.) degrees in synthetic organic chemistry from the University of Oxford under the supervision of Professor G.W.J. Fleet. He is co-author or co-inventor on many journal articles, presentations and patent applications.
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